Value AD
CAN BE
ALTERNATIVE
INVESTMENT
Screening and Functional Validation of Human Birth Defects Genomic Variants (R01 Clinical Trial Not Allowed)
PAR-21-229
National Institutes of Health
Funding Opportunity Number: PAR-21-229
Opportunity Category: Discretionary
CFDA Number(s): 93.121 -- Oral Diseases and Disorders Research,93.351 -- Research Infrastructure Programs,93.865 -- Child Health and Human Development Extramural Research
Cost Sharing or Matching Requirement: No
Posted Date: May 05, 2021 12:00:00 AM EDT
Closing Date: May 07, 2025 12:00:00 AM EDT
Award Ceiling: $499999
Award Floor: none
Eligible Applicants: City or township governments,Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education,Public and State controlled institutions of higher education,Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education,Special district governments,Others (see text field entitled "Additional Information on Eligibility" for clarification),State governments,Native American tribal governments (Federally recognized),Native American tribal organizations (other than Federally recognized tribal governments),Small businesses,County governments,Independent school districts,Public housing authorities/Indian housing authorities,Private institutions of higher education,For profit organizations other than small businesses
Additional Information on Eligibility: Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.
Agency Name: National Institutes of Health
Description: Rapid advances in genotyping and next generation sequencing technologies have led to the identification of genetic variants that are associated with a wide variety of congenital defects including structural birth defects (SBDs), intellectual developmental disabilities (IDDs) and inborn errors of metabolism (IEMs). Large quantities of genomic data collected from pediatric birth defects cohorts are available to the research community through several databases such as the Database of Genotypes and Phenotypes (dbGaP), the Gabriella Miller Kids First Data Resource Portal, the European Genome-Phenome Archive and Clinical Genome Resource (ClinGen). The purpose of this initiative is to promote the screening, functional validation and characterization of birth defects-associated genetic variants identified through public facing databases and individual efforts using in-silico tools, appropriate animal models, in vitro systems or multi-pronged approaches. This initiative addresses a challenging gap between identifying sequence variations of potential interest and recognizing which of those variations have functional effects on the phenotype of interest.
Grantor Contact Information: NIH OER Webmaster grantsinfo@nih.gov
