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    Country
    Opportunity Status
    Funding Instrument Type
    Category
    Clear

    Preclinical Proof of Concept Studies for Rare Diseases (R21 Clinical Trial Not Allowed)

    RFA-TR-24-023

    National Institutes of Health

    Opening date 3 Apr 2024, 12:00AM

    Closing date 2 Jun 2026, 12:00AM

    Funding Opportunity Number: RFA-TR-24-023

    Opportunity Category: Discretionary

    CFDA Number(s): 93.350 -- National Center for Advancing Translational Sciences

    Cost Sharing or Matching Requirement: No

    Posted Date: Apr 03, 2024 12:00:00 AM EDT

    Closing Date: Jun 02, 2026 12:00:00 AM EDT

    Award Ceiling: $275000

    Award Floor: none

    Eligible Applicants: Native American tribal governments (Federally recognized),Others (see text field entitled "Additional Information on Eligibility" for clarification),Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education,Native American tribal organizations (other than Federally recognized tribal governments),For profit organizations other than small businesses,State governments,City or township governments,County governments,Independent school districts,Small businesses,Special district governments,Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education,Public housing authorities/Indian housing authorities,Public and State controlled institutions of higher education,Private institutions of higher education

    Additional Information on Eligibility: Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

    Agency Name: National Institutes of Health

    Description: This notice of funding opportunity (NOFO) provides funding to conduct efficacy studies in an established rare disease preclinical model to demonstrate that a proposed therapeutic agent warrants further development. In addition to preclinical efficacy, accompanying pharmacodynamic and pharmacokinetic studies would be supported. Therapeutic agents include small molecules, biologics or biotechnology-derived products. The goal of this NOFO is to spur therapeutic development for a variety of rare diseases by advancing projects to the point where they would attract subsequent investment supporting full Investigational New Drug (IND) application development or progression to clinical trials in the case of repurposing or repositioning.

    Grantor Contact Information: NIH Grants Information grantsinfo@nih.gov

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