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    Country
    Opportunity Status
    Funding Instrument Type
    Category
    Clear

    Mechanistic Investigations into ADRD Associated Protein Structures in Biological Settings (R01 - Clinical Trial Not Allowed)

    PAR-24-234

    National Institutes of Health

    Opening date 5 Jun 2024, 12:00AM

    Closing date 4 Oct 2024, 12:00AM

    Funding Opportunity Number: PAR-24-234

    Opportunity Category: Discretionary

    CFDA Number(s): 93.853 -- Extramural Research Programs in the Neurosciences and Neurological Disorders,93.866 -- Aging Research

    Cost Sharing or Matching Requirement: No

    Posted Date: Jun 05, 2024 12:00:00 AM EDT

    Closing Date: Oct 04, 2024 12:00:00 AM EDT

    Award Ceiling: $500000

    Award Floor: none

    Eligible Applicants: Private institutions of higher education,State governments,Small businesses,Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education,Public housing authorities/Indian housing authorities,Public and State controlled institutions of higher education,Native American tribal organizations (other than Federally recognized tribal governments),Independent school districts,County governments,Special district governments,Native American tribal governments (Federally recognized),City or township governments,Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education,Others (see text field entitled "Additional Information on Eligibility" for clarification),For profit organizations other than small businesses

    Additional Information on Eligibility: Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

    Agency Name: National Institutes of Health

    Description: Advances in structural biology have enabled the characterization of large protein assemblies that are linked to AD/ADRD pathology. However, most structural biology approaches require purified samples from cells and tissues or use recombinant bacterial proteins. The derived structures using ex-vivo material may not report the diversity of physiologically relevant species because reconstruction relies on class averaging that is biased towards dominant conformations that survive methodological processing. Recent developments in structural biology offer the possibility of in situ characterization of specific macromolecular assemblies. Structural information of protein assemblies and aggregates in their native cellular and tissue environments could facilitate rational structure-based ligand development. Currently, PET ligands that specifically identify and monitor the accumulation of aggregated and misfolded proteins in AD/ADRD patients are lacking.

    Grantor Contact Information: NIH Grants Information grantsinfo@nih.gov

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