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    Clear

    Integrating Biospecimen Science Approaches into Clinical Assay Development (U01 Clinical Trial Not Allowed)

    PAR-22-049

    National Institutes of Health

    Opening date 21 Oct 2021, 12:00AM

    Closing date 13 Sep 2023, 12:00AM

    Funding Opportunity Number: PAR-22-049

    Opportunity Category: Discretionary

    CFDA Number(s): 93.393 -- Cancer Cause and Prevention Research

    Cost Sharing or Matching Requirement: No

    Posted Date: Oct 21, 2021 12:00:00 AM EDT

    Closing Date: Sep 13, 2023 12:00:00 AM EDT

    Award Ceiling: $250000

    Award Floor: none

    Eligible Applicants: City or township governments,Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education,For profit organizations other than small businesses,Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education,County governments,Public and State controlled institutions of higher education,Native American tribal organizations (other than Federally recognized tribal governments),Special district governments,Others (see text field entitled "Additional Information on Eligibility" for clarification),Public housing authorities/Indian housing authorities,Small businesses,Native American tribal governments (Federally recognized),Private institutions of higher education,State governments,Independent school districts

    Additional Information on Eligibility: Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

    Agency Name: National Institutes of Health

    Description:

    This Funding Opportunity Announcement (FOA) will support extramural research to investigate and mitigate challenges facing clinical assay development and subsequent analytical validation due to preanalytical variability in tumor tissue biopsies, blood biospecimens utilized as liquid biopsies", or other biospecimens as described in this FOA. Extramural research funded under this FOA may include investigations of preanalytical variability associated with the procurement and study of small biopsies (core biopsies, small excision samples), blood utilized for "liquid biopsies", tissue swabs, tissue secretions, pleural and esophageal aspirates, feces, or bodily fluids like sweat, urine, CSF, breast milk and saliva. Investigator-designed experiments will explore how different biospecimen preanalytical conditions affect emerging and clinically relevant biomarkers quantified by a variety of testing platforms. The results from this research program will improve the understanding of how analytical quantification of clinically relevant biomarkers is affected by variation in biospecimen collection, processing, and storage procedures. The overall goal is to expedite biomarker clinical assay development through evidence-based standardization of biopsy handling practices.

    Grantor Contact Information: NIH OER Webmaster OERWebmaster03@od.nih.gov

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