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    Centers for Collaborative Research in Fragile X and FMR1-Associated Conditions (P50 Clinical Trial Optional)

    RFA-HD-25-002

    National Institutes of Health

    Opening date 7 Jun 2024, 12:00AM

    Closing date 6 Aug 2024, 12:00AM

    Funding Opportunity Number: RFA-HD-25-002

    Opportunity Category: Discretionary

    CFDA Number(s): 93.173 -- Research Related to Deafness and Communication Disorders,93.242 -- Mental Health Research Grants,93.853 -- Extramural Research Programs in the Neurosciences and Neurological Disorders,93.865 -- Child Health and Human Development Extramural Research

    Cost Sharing or Matching Requirement: No

    Posted Date: Jun 07, 2024 12:00:00 AM EDT

    Closing Date: Aug 06, 2024 12:00:00 AM EDT

    Award Ceiling: none

    Award Floor: none

    Eligible Applicants: State governments,Public and State controlled institutions of higher education,Others (see text field entitled "Additional Information on Eligibility" for clarification),Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education,Native American tribal organizations (other than Federally recognized tribal governments),City or township governments,For profit organizations other than small businesses,Special district governments,Native American tribal governments (Federally recognized),Independent school districts,Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education,Small businesses,County governments,Public housing authorities/Indian housing authorities,Private institutions of higher education

    Additional Information on Eligibility: Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organization) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

    Agency Name: National Institutes of Health

    Description:

    This Notice of Funding Opportunity (NOFO) invites new applications for Centers for Collaborative Research in Fragile X andFMR1-Associated Conditions (hereafter termed "Fragile X Centers").Despite many remarkable advances in fundamental knowledge about FMR1-associated conditions, gaps in knowledge remain about the processes that drive the variability in clinical features (phenotypic heterogeneity) among affected individuals. In this round of competition, therefore, all centers will be required to identify an overarching theme directed at broadening our understanding of factors underlying the phenotypic heterogeneity and/or variability in response to interventions seen in one or more FMR1 associated conditions.Successful Fragile X Centers will be composed of multidisciplinary teams of basic, translational, clinical, and/or data science investigators applying precision medicine approaches (seeking to understand which mechanisms and interventions are most applicable to specific individuals or groups) to address the center's proposed overarching theme.This NOFO includes specific requirements about inclusion of research on human subjects or human phenotypic data; diversity of participants or materials being studied; the types of allowable clinical trials; and involvement of early-stage investigators. Applications that do not adhere to these requirements will be considered nonresponsive to this NOFO and will be withdrawn.In addition, this NOFO requires a Plan for Enhancing Diverse Perspectives (PEDP), which will be assessed as part of the scientific and technical peer review evaluation. Applications that fail to include a PEDP will be considered incomplete and will be withdrawn.Applicants are strongly encouraged to read the NOFO instructions carefully and view the availablePEDP guidance material.

    Grantor Contact Information: NIH Grants Information grantsinfo@nih.gov

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