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    BRAIN Initiative: Exploratory Research Opportunities Using Invasive Neural Recording and Stimulating Technologies in the Human Brain (R61 Basic Experimental Studies with Humans Required)

    RFA-DC-24-001

    National Institutes of Health

    Opening date 31 Mar 2023, 12:00AM

    Closing date 19 Sep 2025, 12:00AM

    Funding Opportunity Number: RFA-DC-24-001

    Opportunity Category: Discretionary

    CFDA Number(s): 93.173 -- Research Related to Deafness and Communication Disorders,93.213 -- Research and Training in Complementary and Integrative Health,93.242 -- Mental Health Research Grants,93.279 -- Drug Abuse and Addiction Research Programs,93.286 -- Discovery and Applied Research for Technological Innovations to Improve Human Health,93.853 -- Extramural Research Programs in the Neurosciences and Neurological Disorders,93.865 -- Child Health and Human Development Extramural Research,93.866 -- Aging Research,93.867 -- Vision Research

    Cost Sharing or Matching Requirement: No

    Posted Date: Mar 31, 2023 12:00:00 AM EDT

    Closing Date: Sep 19, 2025 12:00:00 AM EDT

    Award Ceiling: none

    Award Floor: none

    Eligible Applicants: For profit organizations other than small businesses,State governments,Others (see text field entitled "Additional Information on Eligibility" for clarification),City or township governments,Independent school districts,Native American tribal organizations (other than Federally recognized tribal governments),Public housing authorities/Indian housing authorities,County governments,Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education,Public and State controlled institutions of higher education,Native American tribal governments (Federally recognized),Private institutions of higher education,Small businesses,Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education,Special district governments

    Additional Information on Eligibility: Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

    Agency Name: National Institutes of Health

    Description: Invasive surgical procedures offer the opportunity for unique intracranial interventions such as the ability to record and stimulate intracranially within precisely localized brain structures in humans. Human studies using invasive technology are often constrained by a limited number of patients and resources available to implement complex experimental protocols and need to be aggregated in a manner that addresses research questions with appropriate statistical power. Therefore, this RFA seeks applications to assemble diverse, integrated, multi-disciplinary teams that cross boundaries of interdisciplinary collaboration to overcome these fundamental barriers and to investigate high-impact questions in human neuroscience. The research should be offered as exploratory research and planning activities to establish feasibility, proof-of-principle and early-stage development that, if successful, would support, enable, and/or lay the groundwork for a potential, subsequent Research Opportunities Using Invasive Neural Recording and Stimulating Technologies in the Human Brain, as described in the companion FOA (RFA-NS-22-041). Projects should maximize opportunities to conduct innovative in vivo neuroscience research made available by direct access to the brain from invasive surgical procedures. Projects should employ approaches guided by specified theoretical constructs and by quantitative, mechanistic models where appropriate. Awardees will join a consortium working group, coordinated by the NIH, to identify consensus standards of practice, including neuroethical considerations, to collect and provide data for ancillary studies, and to aggregate and standardize data for dissemination among the wider scientific community.

    Grantor Contact Information: NIH Grants Information grantsinfo@nih.gov

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