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    Country
    Opportunity Status
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    Clear

    Access and Manipulation of Brain Cell Subtypes Implicated in Aging and AD/ADRD (R61/R33 Clinical Trial Not allowed)

    RFA-AG-25-024

    National Institutes of Health

    Opening date 16 May 2024, 12:00AM

    Closing date 7 Oct 2024, 12:00AM

    Funding Opportunity Number: RFA-AG-25-024

    Opportunity Category: Discretionary

    CFDA Number(s): 93.866 -- Aging Research

    Cost Sharing or Matching Requirement: No

    Posted Date: May 16, 2024 12:00:00 AM EDT

    Closing Date: Oct 07, 2024 12:00:00 AM EDT

    Award Ceiling: none

    Award Floor: none

    Eligible Applicants: Special district governments,Public housing authorities/Indian housing authorities,County governments,State governments,Native American tribal governments (Federally recognized),Private institutions of higher education,Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education,Independent school districts,For profit organizations other than small businesses,Public and State controlled institutions of higher education,Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education,Native American tribal organizations (other than Federally recognized tribal governments),Small businesses,City or township governments,Others (see text field entitled "Additional Information on Eligibility" for clarification)

    Additional Information on Eligibility: Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

    Agency Name: National Institutes of Health

    Description: This Notice of Funding Opportunity (NOFO) invites applications proposing innovative strategies to target and manipulate brain cell subtypes that are altered in aging, Alzheimer's Disease (AD), and AD-Related Dementias (ADRDs). ADRDs include frontotemporal disorders (FTD), Lewy body dementia (LBD), vascular contributions to cognitive impairment and dementia (VCID), and multiple etiology dementias (MED). Specifically, the goal of the NOFO is to encourage the development and utilization of sophisticated tools that pair breakthroughs in adeno-associated virus (AAV) capsid engineering with enhancer element identification to (1) optimize precise targeting of disease-relevant cell subtypes in aged and degenerating mammalian brains and (2) monitor and/or manipulate these cells in vivo to address mechanistic hypotheses related to brain aging and AD/ADRD in animals models. To achieve this goal, the NOFO utilizes the R61/R33 Exploratory/Developmental Phased Award activity code. The R61 phase provides up to 2 years of support for pilot activities to demonstrate proof-of-principle. The R33 phase provides up to 3 years of support for implementation activities including hypothesis testing.

    Grantor Contact Information: NIH Grants Information grantsinfo@nih.gov

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